1054-155 Antiangiogenic therapy of early atherosclerosis with paramagnetic ανβ3-integrin-targeted fumagillin nanoparticles
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چکیده
منابع مشابه
Endothelial 3 Integrin–Targeted Fumagillin Nanoparticles Inhibit Angiogenesis in Atherosclerosis
Objective—Angiogenic expansion of the vasa vasorum is a well-known feature of progressive atherosclerosis, suggesting that antiangiogenic therapies may stabilize or regress plaques. 3 Integrin–targeted paramagnetic nanoparticles were prepared for noninvasive assessment of angiogenesis in early atherosclerosis, for site-specific delivery of antiangiogenic drug, and for quantitative follow-up of ...
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Patrick M. Winter, PhD, Anne M. Morawski, BS, Shelton D. Caruthers, PhD, Thomas D. Harris, PhD, Grace Hu, PhD, Ralph W. Fuhrhop, Huiying Zhang, MD, John S. Allen, BS, Elizabeth K. Lacy, BS, Todd A. Williams, BS, Samuel A. Wickline, MD, Gregory M. Lanza, MD, PhD. Cardiology, Washington University, St. Louis, MO, USA, Philips Medical Systems, Cleveland, OH, USA, BristolMyers Squibb Medical Imagin...
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Zhang, Todd A. Williams, John S. Allen, Elizabeth K. Lacy, J. David Robertson, Gregory M. Patrick M. Winter, Anne M. Morawski, Shelton D. Caruthers, Ralph W. Fuhrhop, Huiying Targeted Nanoparticles − -Integrin 3 β v α Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2003 American Heart Association, Inc. All rights re...
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Photoacoustic (PA) tomography enables multiscale, multicontrast and high-resolution imaging of biological structures. In particular, contrast-enhanced PA imaging offers high-sensitivity noninvasive imaging of neovessel sprout formation and nascent tubules, which are important biomarkers of malignant tumors and progressive atherosclerotic disease. While gold nanoparticles or nanorods have been u...
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Molecular ultrasound is capable of elucidating the expression of angiogenic markers in vivo. However, the capability of the method for volumetric "multitarget quantification" and for the assessment of antiangiogenic therapy response has rather been investigated. Therefore, we generated cyanoacrylate microbubbles linked to vascular endothelial growth factor receptor 2 (VEGFR2) and alphavbeta3 in...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2004
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(04)91363-0